Approved by the FDA in 1980, trimethoprim as a single agent is used only for the treatment of uncomplicated urinary tract infections. The argument for trimethoprim as a single agent was summarized in 1979 by Wormser and Deutsch.118 They point out that several studies comparing trimethoprim with TMP-SMX for the treatment of chronic urinary tract infections found no statistically relevant difference between the two courses of therapy. Furthermore, some patients cannot take sulfonamide products for the reasons discussed previously in this chapter. The concern is that when used as a single agent, bacteria now susceptible to trimethoprim will rapidly develop resistance. In combination with a sulfonamide, however, the bacteria will be less likely to do so. That is, they will not survive long enough to easily develop resistance to both drugs.

Sulfamethoxazole and Trimethoprim

The synergistic action of the combination of these two drugs is discussed previously in this chapter.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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