Nicotinic Receptor Subtypes

Nicotinic receptors located in the neuromuscular junction differ from those on neurons, such as those in the CNS and autonomic ganglia, in that they have different ligand specificities. Nicotinic receptors at the neuromuscular junction (N1) are blocked by succinylcholine, d-tubocurarine, and decamethonium and stimulated by phenyltrimethylammo-nium. N2-nicotinic receptors are found in autonomic ganglia. They are blocked by hexamethonium and trimethaphan but stimulated by tetramethylammonium and dimethyl-4-phenylpiperazinium (DMPP). Nicotinic receptor subtypes

Figure 17.2 • Model of the nicotinic receptor consisting of five protein subunits embedded in a cell membrane, based on electron microscopy and neutron scattering data. Jagged lines represent oligosaccharide chains on the upper part of the receptor. A 43K protein is bound to the receptor on the cy-tosolic side of the cell membrane. The ACh-binding sites are shown on the two-subunit proteins. (Reprinted with permission from Lindstrom, J. M., et al.: Cold Spring Harbor Symp. Quant. Biol. 48:93, 1983.)

Figure 17.2 • Model of the nicotinic receptor consisting of five protein subunits embedded in a cell membrane, based on electron microscopy and neutron scattering data. Jagged lines represent oligosaccharide chains on the upper part of the receptor. A 43K protein is bound to the receptor on the cy-tosolic side of the cell membrane. The ACh-binding sites are shown on the two-subunit proteins. (Reprinted with permission from Lindstrom, J. M., et al.: Cold Spring Harbor Symp. Quant. Biol. 48:93, 1983.)

have also been identified in many regions of the CNS; however, their pharmacological function is not yet fully understood.10 Even so, great attempts are being made to understand the role of so many receptor subtypes, particularly those found in the CNS.11,12

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