Nr

Inactive renal elimination

sufficiently lipophilic to cross the blood-brain barrier, yet it displays no CNS-opioid effects. The reason for this is that it is actively pumped out of the brain via the P-glycoprotein pump (MDR1).87 Knockout mice with the P-glycoprotein pump genetically removed were given radiolabeled loperamide and sacrificed 4 hours later. The [3H]loperamide concentrations were measured and compared with wild-type mice. A 13.5-fold increase in loperamide concentration was found in the brain of the knockouts. In addition, the mice lacking the P-glycoprotein pump displayed pronounced signs of central opiate agonism.87 Loperamide is available as 2-mg capsules for treatment of acute and chronic diarrhea. Recommended dosage is 4 mg initially, with 2 mg after each loose stool for a maximum of 16 mg/d.

Was this article helpful?

0 0
How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

Get My Free Ebook


Post a comment