O Acknowledgment

The author wishes to express his gratitude to Dr. Paul Goldsmith for proofreading. Portions of this text were taken from Dr. Rodney L. Johnson's chapter in the 11th edition of this book.

review questions

1. What functional group interactions between the catecholamines and adrenoceptors are most likely? Which functional groups are considered pharmacophores of catecholamines?

2. Which of the following drugs would be resistant to metabolism by COMT and why?

3. Which of the drug(s) shown would be the least orally active and have the shortest duration of action and why?

4. Which of the following drugs is the most likely to be se- 5. Which of the following drugs is considered to be a pro-

lective [2-agonist?


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