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Novobiocin Sodium

In the search for new antibiotics, three different research groups independently isolated novobiocin, streptonivicin (Albamycin) from Streptomyces spp. It was reported first in 1955 as a product of S. spheroides and S. niveus. Currently, it is produced from cultures of both species. Until the common identity of the products obtained by the different research groups was ascertained, the naming of this compound was confused. Its chemical identity was established as 7-[4-(car-bamoyloxy)tetrahydro-3-hydroxy-5-methoxy-6,6-di-methylpyran-2-yloxyl-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methylcoumarin by Shunk et al.272 and Hoeksema et al.273 and confirmed by Spencer et al.274,275 Chemically, novobiocin has a unique structure among antibiotics, though, like several others, it possesses a glyco-sidic sugar moiety. The sugar in novobiocin, devoid of its carbamate ester, has been named noviose and is an aldose with the configuration of l-lyxose. The aglycon moiety has been termed novobiocic acid.

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Healthy Sleep

Healthy Sleep

A Guide to Natural Sleep Remedies. Many of us experience the occasional night of sleeplessness without any consequences. It is when the occasional night here and there becomes a pattern of several nights in arow that you are faced with a sleeping problem. Repeated loss of sleep affects all areas of your life The physical, the mental, and theemotional. Sleep deprivation can affect your overall daily performance and may even havean effecton your personality.

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