O

results in a selective antibacterial effect because susceptible bacteria cannot utilize preformed folate from the environment.

It was soon noted that PteGlu and naturally occurring folates differed in that the natural forms had a reduced ring B of the pteridine moiety; more than one Glu attached, which is referred to as pteroylpolyglutamates (PteGlun); and a single carbon unit attached to the nitrogen at position 5 or 10. As a result, it was first recommended that folic acid be used to denote the fully oxidized, monoglutamate form without the single carbon unit and folate was used to denote all forms that possess biological activity as the vitamin. Currently, folate (the preferred term) specifically refers to pteroylglutamate and folic acid refers to pteroyl-glutamic acid.200 Folate can also be used generically to refer to any of the members of the group of pteroylgluta-mates, their mixtures, differing one-carbon substituents, level of reduction, or number of glutamate residues. Because of this dual use of the term folate, the authors have chosen to use the term folate only in its generic sense throughout this chapter. This will avoid confusion with the fully oxidized form, folic acid, which is the major form available for vitamin supplementation.

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook


Post a comment