At the cellular level, three basic mechanisms are believed to contribute to the antiepileptic action of the currently marketed anticonvulsants.18,19 These are (a) modulation of voltage-gated ion channels (Na+, Ca2+, and K+), (b) enhancement of y-aminobutyric acid (GABA)-mediated inhibitory neurotransmission, and (c) attenuation of excitatory (particularly glutamate-mediated) neurotransmission in the brain. Many of AEDs, especially the newer drugs, work by more than one of the above mechanisms of actions, therefore possessing a broader spectrum of antiepilep-tic action.
Voltage-Gated Ion Channels as Targets for Anticonvulsants
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Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...