Sulfasalazine (2-hydroxy-5[[4-[(2-pyridinylamino)sulfonyl] phenyl]azo]benzoic acid or 5-[p-(2-pyridylsulfamoyl) phenylazo] salicylic acid) is a brownish yellow, odorless powder, slightly soluble in alcohol but practically insoluble in water, ether, and benzene.

Sulfasalazine is broken down in the body to m-aminosal-icylic acid and sulfapyridine. The drug is excreted through the kidneys and is detectable colorimetrically in the urine, producing an orange-yellow color when the urine is alkaline and no color when the urine is acid.

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