Chloramphenicol Sodium Succinate
Chloramphenicol sodium succinate is the water-soluble sodium salt of the hemisuccinate ester of chloramphenicol. Because of the low solubility of chloramphenicol, the sodium succinate is preferred for intravenous administration. The availability of chloramphenicol from the ester following intravenous administration is estimated to be 70% to 75%; the remainder is excreted unchanged.269,270 Poor availability of the active form from the ester following intramuscular injection precludes attaining effective plasma levels of the antibiotic by this route. Orally administered chloramphenicol or its palmitate ester actually gives higher plasma levels of the active antibiotic than does intravenously administered chlo-ramphenicol sodium succinate.270,271 Nonetheless, effective concentrations are achieved by either route.
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