Technetium (99mTc) Mertiatide
Technetium ("mTc) Oxidronate Injection.
Technetium (99mTc) oxidronate (99mTc-HDP)24 is a hydrox-ylated diphosphonate complex with technetium-99m also indicated for bone imaging to identify areas of altered osteo-genesis. The additional hydroxyl group on the methylene spacer connecting the phosphonate groups of medronate provides higher binding affinity for hydroxyapatite crystals in bone; however, subjective criteria indicate no advantage to use of this agent.
The relatively weak complex is prepared by adding sodium pertechnetate (99mTc) to the shielded vial containing oxidronate sodium, stannous chloride, sodium chloride, and gentisic acid. Radiolabeling requires an incubation of 30 to 60 seconds, and the recommended shelf life is 8 hours.
The recommended dose is an intravenous injection of 10 to 20 mCi (370-740 MBq). The patient should void immediately prior to imaging to minimize interference from the bladder. Images are obtained 1 to 4 hours postinjection.
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