Pharmacokinetic Properties

Haloperidol is the prototype of the butyrophenones and the one that has been studied the most. Haloperidol and droperi-dol, the two butyrophenones available in the United States, are well absorbed from the GI tract.83 First-pass metabolism in the liver reduces the bioavailability of haloperidol to approximately 60%. Haloperidol undergoes extensive metabolism including N-dealkylation, reduction, oxidation, and N-oxidation. Most of the metabolites of haloperidol are inactive. Hydroxyhaloperidol, the reduced (ketone) metabolite of haloperidol, is the only active metabolite and it is also subject to extensive hepatic metabolism (Fig. 13.7).83,95

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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