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Captopril. Captopril, 1-[(2S)-3-mercapto-2-methyl-1-ox-opropionyl]proline (Capoten), blocks the conversion of angiotensin I to angiotensin II by inhibiting the converting enzyme. The rational development of captopril as an inhibitor of ACE was based on the hypothesis that ACE and car-boxypeptidase A functioned by similar mechanisms. It was noted that d-2-benzylsuccinic acid7 was a potent inhibitor of carboxypeptidase A, but not ACE. By use of this small

Figure 18.4 • Model showing cleavage of the histidine-phenylalanine residue of angiotensin I by ACE to form the octapeptide antiotensin II and the dipeptide residue of histi-dine and leucine.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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