Figure 23.12 • General structure of the dibenzocyclo-heptenes and dibenzocycloheptanes.

hepta(1,2-b]pyridine maleate (1:2) (Optimine), is a potent, long-acting antihistaminic with antiserotonin activity. In early testing, azatadine exhibited more than three times the potency of chiorpheniramine in the isolated guinea pig ileum screen and more than seven times the oral potency of chlorpheniramine in protection of guinea pigs against a double lethal dose of intravenously administered histamine.41

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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