R

Figure 23.12 • General structure of the dibenzocyclo-heptenes and dibenzocycloheptanes.

hepta(1,2-b]pyridine maleate (1:2) (Optimine), is a potent, long-acting antihistaminic with antiserotonin activity. In early testing, azatadine exhibited more than three times the potency of chiorpheniramine in the isolated guinea pig ileum screen and more than seven times the oral potency of chlorpheniramine in protection of guinea pigs against a double lethal dose of intravenously administered histamine.41

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