R

Morphinan

R= OH (-) Levorphanol oral = 2 mg R= OCH3 (+) Dextromethorphan

conj = glucuronide or sulfate

Figure 24.8 • Metabolism of morphine and codeine.

conj = glucuronide or sulfate

Figure 24.8 • Metabolism of morphine and codeine.

sulfate salt is formed for both oral, IV, and suppository use. The usual starting parenteral dose of morphine in adults is 2.5 to 5 mg q 4 hours. Morphine is available for oral use both as an immediate release and sustained release formulation. The immediate release preparations are dosed q 4 hours, and the sustained release formulations are dosed q 12 to q 24 hours depending on the formulation.

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Healthy Sleep

Healthy Sleep

A Guide to Natural Sleep Remedies. Many of us experience the occasional night of sleeplessness without any consequences. It is when the occasional night here and there becomes a pattern of several nights in arow that you are faced with a sleeping problem. Repeated loss of sleep affects all areas of your life The physical, the mental, and theemotional. Sleep deprivation can affect your overall daily performance and may even havean effecton your personality.

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