Dibucaine is a topical amide anesthetic available in over-the-counter creams and ointments used to treat minor conditions such as sunburns and hemorrhoids. Dibucaine has been found to be highly toxic when taken orally, inducing seizures, coma, and death in several children who accidentally ingested it.99 Metabolites of dibucaine identified in the urine of rats, rabbits, and humans included hydroxyl-ated metabolites of the quinoline ring, monohydroxylated and dihydroxylated metabolites of the O-alkyl side chain (2'- and 3'-position), and the N-de-ethylated dibucaine metabolite.100
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