Semisynthetic Analogs

Because bacterial and hepatic oxidation of the 17^-hydroxyl to the 17-one is a key component of metabolic inactivation, 17a-alkyl groups have been added to prevent oxidation of the alcohol. Even though 17a-methyltestosterone is only about half as active as testosterone, it can be taken orally because its half-life is longer than that of testosterone. 17a-ethyl-testosterone has greatly reduced activity, as shown in Table 25.5.98 As mentioned previously, addition of an a-alkynyl group provides more progestogenic action than androgenic

TABLE 25.5 Androgenic Activities of Some Androgens

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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