Semisynthetic Analogs

Because bacterial and hepatic oxidation of the 17^-hydroxyl to the 17-one is a key component of metabolic inactivation, 17a-alkyl groups have been added to prevent oxidation of the alcohol. Even though 17a-methyltestosterone is only about half as active as testosterone, it can be taken orally because its half-life is longer than that of testosterone. 17a-ethyl-testosterone has greatly reduced activity, as shown in Table 25.5.98 As mentioned previously, addition of an a-alkynyl group provides more progestogenic action than androgenic

TABLE 25.5 Androgenic Activities of Some Androgens

Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment