The Classical Complement Pathway

The classical complement pathway differs from the alternative pathway in that it requires a trigger in the form of an antigen-Ab complex. Only two antibodies can fix complement—IgG and IgM. The classical pathway is shown in Figure 5.3. The small fragments that are cleaved from the proenzymes have activities such as chemotactic stimulation and anaphylaxis. The bar over the names of some components of the pathway denotes an active complex. Note that the classical pathway does not operate with C1 to C9 in sequence. Rather, the sequence is C1, C4, C2, C3, C5, C6, C7, C8, and C9.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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