The Gold Compounds

The gold salts, gold sodium thiomalate (Aurolate), auro-thioglucose (Solganal), and auranofin (Ridaura) have been known to be effective in the treatment of RA for more than 60 years.225 Recent findings have suggested that, auranofin, an orally active gold salt, inhibits Nuclear factor kB (NF-kB) activation TLR4-mediated activation of the signaling pathway that leads to the blocking of the formation of inflammatory gene product such as cytokines and COX-2.238 Because zinc is a necessary component of NF-kB, a transcription factor that is critical for its DNA binding, Yang et al.239 suggested that auranofin works by oxidizing the zinc containing thiolate anions of NF-kB into a disulfide, thus abolishing the DNA binding requirement for gene expression. However, few patients take gold salt therapy for longer than 5 years because of their toxicities including mu-cocutaneous reactions, proteinuria, and cytopenias.222

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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