Although not requisite for activity, a suitably placed alcoholic hydroxyl group enhances antimuscarinic activity over that of a similar compound without the hydroxyl group. The position of the hydroxyl group relative to the nitrogen appears to be fairly critical, with the diameter of the receptive area estimated to be about 2 to 3 A. It is assumed that the hy-droxyl group contributes to the strength of binding, probably by hydrogen bonding to an electron-rich portion of the receptor surface.
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