Therapeutic Uses

Folic acid is used in the treatment of known or suspected folate deficiency or increased need as occurs during

Tetrahyd rof olate Tetra hyd rofolates

(H4PteGlu) (H4PteGlun)

Figure 28.43 • Bioactivation of folic acid to tetrahydrofolate polyglutamates.

Figure 28.44 • Interconversion of active folates.
TABLE 28.11 Folic Acid-Dependent Enzymes


EC Number


Methionine synthase

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