2-Oxo-quazepam (L)

Figure 12.2 • Metabolism of benzodiazepines and their duration of action.

lized by cytochrome P450 (CYP) 3A4 and CYP2C19. CYP3A4 inhibitors (erythromycin, clarithromycin, ritonavir, itraconazole, ketoconazole, nefazodone, and grapefruit juice) can affect their metabolism. However, they do not induce the metabolism of other drugs. Therefore, the drugs have fewer drug interactions than barbiturates. In addition, they have lower abuse potential and a much greater margin of safety than the barbiturates.

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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