V

2-Oxo-quazepam (L)

Figure 12.2 • Metabolism of benzodiazepines and their duration of action.

lized by cytochrome P450 (CYP) 3A4 and CYP2C19. CYP3A4 inhibitors (erythromycin, clarithromycin, ritonavir, itraconazole, ketoconazole, nefazodone, and grapefruit juice) can affect their metabolism. However, they do not induce the metabolism of other drugs. Therefore, the drugs have fewer drug interactions than barbiturates. In addition, they have lower abuse potential and a much greater margin of safety than the barbiturates.

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