Psychiatry

Antidepressants Heterocyclic Compounds AMITRIPTYLINE (Elavll) Start 25 to 100 mg PO qhs gradually increase to usual effective dose of 50 to 300 mg day. Primarily inhibits serotonin reuptake. Demethylated to nortriptyline, which primarily inhibits norepinephrine reuptake. Generic Tabs 10, 25, 50, 75, 100, 150 mg. Elavil brand name no longer available has been retained in this entry for name recognition purposes only. > L 2D - CLOMIPRAMINE (Anafranil) Start 25 mg PO qhs gradually increase to...

Ulcerative Colitis

BALSALAZIDE (Colazal) 2.25 g PO tid for 8 to 12 weeks. Generic Trade Caps 750 mg. Minimal absorption 2B MESALAMINE (5-aminosalicylic acid, Apriso, 5-ASA, Asacol, Lialda, Pentasa, Canasa, Rowasa, Mesasal, Salofalk) Apriso 1.5 g (4 caps) PO qam. Asacol 800 to 1600 mg PO tid. Pentasa 1000 mg PO qid. Lialda 2.4 to 4.8 g PO daily with a meal. Canasa 500 mg PR bid to tid or 1000 mg PR qhs. Trade only Delayed-release tabs 400, 800 mg (Asacol), controlled-release cap 250, 500 mg (Pentasa),...

Statins

Minimum Dose for 30-40 LDL Reduction Baseline for all doses Get LFTs prior to & 3 months after dose increase to 80 mg, then semiannually for first year. *Adapted from Circulation 2004 110 227-239. **Data taken from prescribing information for primary hypercholesterolemia. LDL low-density lipoprotein, LFT l iver function tests. Will get 6 decrease in LDL with every doubling of dose. ACC AHA NHLBI schedule for LFT monitoring baseline, 12 weeks after starting titrating therapy, annually, when...

Cephalosporins General Antimicrobial Spectrum

1st generation gram positive (including Staph aureus) basic gram neg. coverage 2nd generation diminished Staph aureus, improved gram negative coverage compared to 1st generation some with anaerobic coverage 3rd generation further diminished Staph aureus, further improved gram negative coverage compared to 1st & 2nd generation some with Pseudomonal coverage & diminished gram positive coverage 4th generation same as 3rd generation plus coverage against Pseudomonas CEFPODOXIME (Vantin) 100...

Other Dermatologic Agents

ALITRETINOIN (Panretin) Apply bid to qid to cutaneous Kaposi's lesions Trade only Gel 0.1 60 g. > Not absorbed 2D - ALUMINUM CHLORIDE (Drysol, Certain Dr) Apply qhs. Rx Trade only Soln 20 37.5 mL bottle, 35, 60 mL bottle with applicator. OTC Trade only (Certain Dri) Soln 12.5 36 mL bottle. > K 2 BECAPLERMIN (Regranex) Diabetic ulcers Apply daily. Trade only Gel 0.01 , 2, 15 g. Minimal absorption 2C CALAMINE Apply tid to qid prn for poison ivy oak or insect bite itching. OTC Generic only...

Analgesics

Antirheumatic Agents Biologic Response Modifiers NOTE Death, sepsis, and serious infections (eg, TB & invasive fungal Infections) have been reported. ADALIMUMAB (Humira) RA.psoriatic arthritis, ankylosing spondylitis 40 mg SC q 2 weeks. alone or in combination with methotrexate or other disease-modifying antirheumatic drugs (DMARDs). May increase frequency to once a week if not on methotrexate. Crohn's disease 160 mg SC at week 0. 80 mg at week 2. then 40 mg q other week starting with week...

Info

LEVOTHYROXINE (L-Thyroxine, Levolet, Levo-T, Levothroid, Levoxyl, Novothyrox, Synthroid, Thyro-Tabs, Tirosint, Unithroid, T4, Eltroxin, Euthyrox) Start 100 to 200 mcg PO daily (healthy adults) or 12.5 to 50 mcg PO daily (elderly or CV disease), increase by 12.5 to 25 mcg day at 3 to 8 weeks intervals. Usual maintenance dose 100 to 200 mcg day, max 300 mcg day. Generic Trade Tabs 25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200, 300 mcg. Trade only Caps 25, 50, 75, 100, 125, 150 mcg in 7 days...

Dermatology

ACANYA (clindamycin + benzoyl peroxide) Apply qd. Trade only Gel (clindamycin 1.2 + benzoyl peroxide 2.5 ) 50 g. > K 2C + ADAPALENE (Differin) Apply qhs. Trade only Gel 0.1 , 0.3 (45 g), Cream 0.1 (45 g), Soln 0.1 (30 mL), Swabs 0.1 (60 ea). Bile C AZELAIC ACID (Azelex, Finacea, Finevin) Apply bid. Trade only Cream 20 , 30, 50 g (Azelex), Gel 15 50 g (Finacea). > K 2B BENZACLIN (clindamycin + benzoyl peroxide) Apply bid. Trade only Gel (clindamycin 1 + benzoyl peroxide 5 ) 25, 50 g (jar),...

ML K

POLYETHYLENE GLYCOL (MraLax, GlycoLax) 17 g (1 heaping tablespoon) in 4 to 8 oz water, juice, soda, coffee, or tea PO daily. OTC Trade only (MiraLax) Powder for oral soln 17 g scoop. Rx Generic Trade Powder for oral soln 17 g scoop. Not absorbed 2C POLYETHYLENE GLYCOL WITH ELECTROLYTES (GoLytely, Colyte, TriLyte, NuLytely, Moviprep, HalfLytely and Bisacodyl Tablet Kit, *Klean-Prep, Electropeg, Peg-Lyte OCL) Bowel prep 240 mL q 10 min PO or 20 to 30 mL min per NG until 4L is consumed. Moviprep...

Antivirals Topical

ACYCLOVIR TOPICAL (Zovirax) Herpes genitalis Apply ointment q 3 h (6 times per day) for 7 days. Recurrent herpes labialis Apply cream 5 times per day for 4 days. Trade only Ointment 5 15 g, Cream 5 2, 5 g. > K 2C DOCOSANOL (Abreva) Oral-facial herpes (cold sores) Apply 5 times per day until healed. OTC Trade only Cream 10 2 g. > Not absorbed 2B IMIQUIMOD (Aldara) Genital perianal warts Apply 3 times per week overnight for up to 16 weeks. Wash off after 8 h. Non-hyperkeratotic,...

Antiulcer Helicobacter pylori Treatment

HELIDAC (bismuth subsalicylate + metronidazole + tetracycline) 1 dose PO qid for 2 weeks. To be given with an H2 antagonist. Trade only Each dose consists of bismuth subsalicylate 524 mg (2 X 262 mg) chewable tab + metronidazole 250 mg tab + tetracycline 500 mg cap. > LK 2D - PREVPAC (lansoprazole + amoxicillin + clarithromycin) (*HP-Pac) 1 dose PO bid for 10 to 14 days. Trade only Each does consists of lansoprazole 30 mg cap + amoxicillin 1 g (2 X 500 mg caps), + clarithromycin 500 mg tab....

Famotidine Pepcid Pepcid AC Maximum Strength Pepcid AC 20 mg IV

Q 12 h. 20 to 40 mg PO qhs, or 20 mg PO bid. Generic Trade Tabs 10 mg (OTC, Pepcid AC Acid Controller), 20 mg (Rx and OTC, Maximum Strength Pepcid AC) 40 mg. Rx Trade only Susp 40 mg 5 mL. > LK 2B NIZATIDINE (Axid, Ax id AR) 150 to 300 mg PO qhs, or 150 mg PO bid. OTC Trade only (Axid AR) Tabs 75 mg. Rx Trade only Oral soln 15 mg mL (120, 480 mL). Rx Generic Trade Caps 150, 300 mg. > K 2B PEPCID COMPLETE (famotidine + calcium carbonate + magnesium hydroxide) Treatment of heartburn 1 tab PO...

Colony Stimulating Factors

DARBEPOETIN (Aranesp, NESP) Anemia of chronic renal failure 0.45 mcg kg IV SC once a week, or 0.75 mcg kg q 2 weeks in some nondialysis patients. Cancer chemo anemia 2.25 mcg kg SC weekly, or 500 mcg SC every 3 weeks. Adjust dose based on Hb. Trade only All forms are available with or without albumin. Single-dose vials 25, 40, 60, 100, 200, 300, 500 mcg 1 mL, and 150 mcg 0.75 mL. Single-dose prefilled syringes or autoinjectors 25 mcg 0.42 mL, 40 mcg 0.4 mL, 60 mcg 0.3 mL, 100 mcg 0.5 mL, 150...

Donnatal phenobarbital atropine hyoscyamine scopolamine 1 to

2 tabs caps or 5 to 10 mL PO tid to qid. 1 extended-release tab PO q 8 to 12 h. Trade only Phenobarbital 16.2 mg + hyoscyamine 0.1 mg + atropine 0.02 mg + scopolamine 6.5 mcg in each tab or 5 mL. Extended-release tab 48.6 + 0.3111 + 0.0582 + 0.0195 mg. > LK 2C - GI COCKTAIL (green goddess) Acute GI upset Mixture of Maalox Mylanta 30 mL + viscous lidocaine (2 ) 10 mL + Donnatal 10 mL administered PO in a single dose. > LK 2See individual > See individual HYOSCINE (tBuscopan) Canada GI or...

C

SOLAG (mequinol + tretinoin) (*Solage) Apply to solar lentigines bid. Trade only Soln 30 mL (mequinol 2 + tretinoin 0.01 ). Not absorbed 2X SYNERA (tetracaine + lidocaine topical ) Apply 20 to 30 min prior to superficial dermatological procedure. Trade only Topical patch (lidocaine 70 mg + tetracaine 70 mg. Minimal absorption 2B TRI-LUMA (fluocinolone + hydroquinone + tretinoin) Melasma of the face apply qhs for 4 to 8 weeks. Trade only Cream 30 g (fluocinolone 0.01 + hydroquinone 4 + tretinoin...

Toxicology

TARASCON POCKET PHARMACOPOEIA EDITORIAL STAFF* EDITOR IN CHIEF Richard J Hamilton, MD, FAAEM,FACMT, Professor and Chair, Department of Emergency Medicine, Drexel University College of Medicine, Philadelphia, PA ASSOCIATE EDITORS Adrienne Z. Ables, PharmD, Associate Professor, Spartanburg Family Medicine Residency Program, Spartanburg, SC Jill E. Allen, PharmD, BCPS, Drug Information Consultant, Salt Lake City, UT Kimberly K. Birtcher, MS, PharmD, BCPS, CDE, Clinical Associate Professor,...

Vdt

Chloral hydrate 144b chlorambucil 128b chloramphenicol 33b chlordiazepoxide Gastroenterology Chlordrine SR 85m chlorhexidine gluco- Chloromycetin 33b chlorophyllin copper chlorpheniramine 84t chlorpromazine t top of page m middle of page b bottom of page D,PDA see page 157 cholesterol absorption i n hibitor 43b cholestyramine 42m choline magnesium t top of page m middle of page b bottom of page D,PDA see page 157 Clarinex-D12hour D C 3flflfi--D24-h 85m Claritin-D 12 h 85t Claritin-D 24 h 85t...

X

HDL high density lipoprotein. TG triglycerides. Adapted from NCEP JAMA 2001 285 2486 and prescribing information. 2. Cholestyramine (4-16 g), colestipol (5-20 g), colesevelam (2.6-3.8 g). 3. Ezetimibe (10 mg). When added to statin therapy, will I LDL 25 , HDL 3 , I TG 14 in addition to statin effects. 4. Fenofibrate (145-200 mg), gemfibrozil (600 mg BID). 5. Advicor (20 1000-40 2000 mg). 6. Extended release nicotinic acid (Niaspan 1-2 g), immediate release...

Pulmonary

ALBUTEROL (AccuNeb, Ventolin HFA, Proventil HFA, ProAir HFA, VoSpire ER, Airomir, Asmavent, salbutamol) MDI 2 puffs q 4 to 6 h prn. 0.5 mL of 0.5 soln (2.5 mg) nebulized tid to qid. One 3 mL unit dose (0.083 ) nebulized tid to qid. Caps for inhalation 200 to 400 mcg q 4 to 6 h. 2 to 4 mg PO tid to qid or extended-release 4 to 8 mg PO q 12 h up to 16 mg PO q 12 h. Peds 0.1 to 0.2 mg kg dose PO tid up to 4 mg tid for age 2 to 5 yo, 2 to 4 mg or extended-release 4 mg PO q 12 h for age 6 to 12 yo....

E I

T top of page m middle of page b bottom of page D,PDA see page 157 Erythrocin IV. Erythromid erythromycin. erythromycin base estradiol acetate vaginal ring 122t t top of page m middle of page b bottom of page D,PDA see page 157 estradiol transdermal patch 122b estradiol transdermal spray 122b estrogens conjugated , 125t estrogens synthetic conjugated A 123m estrogens synthetic conjugated B 123m estrogen vaginal ethinyl estradiol Dermatology 58b ethinyl estradiol transdermal 122t ethinyl...

Po

Approximate equiaiialgesic doses as adapted from the 2003 American Pain Society (www.ampainsoc.org) guidelines and the 1992 AHCPR guidelines. Not available n a. See drug entries themselves for starting doses. Many recommend initially using lower than equivalent doses when switching between different opioids. IV doses should be titrated slowly with appropriate monitoring. All PO dosing is with immediate-release preparations. Individualize all dosing, especially in the elderly, children, and in...

Ginsengasian Panax ginseng Ginsana G115 Korean red ginseng

Promoted to improve vitality and well-being 200 mg PO daily. Ginsana 2 caps PO daily or 1 cap PO bid. Ginsana Sport 1 cap PO daily. Preliminary evidence of efficacy for erectile dysfunction. Efficacy unclear for improving physical or psychomotor performance, diabetes, herpes simplex infections, cognitive or immune function. American College of Obstetrics and Gynecologists and North American Menopause Society recommend against use for postmenopausal hot flashes. Not by prescription. 2- - GINSENG...

Urology

ALFUZOSIN UroXatral, Xatral 10 mg PO daily after a meal. Trade only Extended-release tab 10 mg. gt KL 2B - DUTASTERIDE Avodart 0.5 mg PO daily. Trade only Caps 0.5 mg. L 2X - FINASTERIDE Proscar, Propecia Proscar 5 mg PO daily alone or in combination with doxazosin to reduce the risk of symptomatic progression of BPH. Androgenetic alopecia in men Propecia 1 mg PO daily. Generic Trade Tabs 1 mg Propecia , 5 mg Proscar . gt L 2X - TAMSULOSIN Flomax 0.4 mg PO daily, 30 min after a meal. Maximum...

Ophthalmology

NOTE Most eye medications can be administered 1 gtt at a time despite common manufacturer recommendations of 1 to 2 gtts concurrently. Even a single drop is typically more than the eye can hold, and thus a 2nd drop is wasteful and increases the possibility of systemic toxicity. If more medication is desired separate single drops by at least 5 min. Antiallergy Decongestants amp Combinations NAPHAZOLINE Albalon, AllClear. AK-Con, Naphcon, Clear Eyes 1 to 2 gtts qid for up to 3 days. OTC Generic...

Neurology

Alzheimer's Disease Cholinesterase Inhibitors DONEPEZIL Aricept Start 5 mg PO qhs. May increase to 10 mg PO qhs in 4 to 6 weeks. For severe disease MMSE 10 or less , the recommended dose is 10 mg day. Generic Trade Tabs 5, 10 mg. Trade only Orally disintegrating tabs 5, 10 mg. gt LK 2C GALANTAMINE Razadyne, Razadyne ER, Reminyl Extended-release Start 8 mg PO qam with food increase to 16 mg qam after 4 weeks. May increase to 24 mg qam after another 4 weeks. Immediate-release Start 4 mg PO bid...