C

SOLAG (mequinol + tretinoin) (*Solage) Apply to solar lentigines bid. [Trade only: Soln 30 mL (mequinol 2% + tretinoin 0.01%).] ► Not absorbed 2X ►? $$$$

SYNERA (tetracaine + lidocaine—topical ) Apply 20 to 30 min prior to superficial dermatological procedure. [Trade only: Topical patch (lidocaine 70 mg + tetracaine 70 mg.] ►Minimal absorption 2B ►? $$ TRI-LUMA (fluocinolone + hydroquinone + tretinoin) Melasma of the face: apply qhs for 4 to 8 weeks. [Trade only: Cream 30 g (fluocinolone 0.01% + hydroquinone 4% + tretinoin 0.05%).] ►Minimal absorption 2C ►? $$$$ VUSION (miconazole—topical + zinc oxide + white petrolatum) Apply to affected diaper area with each change for 7 days. [Trade only: Ointment 50 g.]

ENDOCRINE & METABOLIC

Androgens / Anabolic Steroids

NOTE See OB/GYN section for other hormones.

METHYLTESTOSTERONE (Android, Methitest, Testred, Virilon) Advancing inoperable breast cancer in women who are 1 to 5 years postmenopausal: 50 to 200 mg/day PO in divided doses. Hypogonadism in men: 10 to 50 mg PO daily. [Generic only: Caps 10 mg, Tabs 10, 25 mg.] >L 2X ►? ©III $$$ NANDROLONE (*Deca-Durabolin) Anemia of renal disease: Women 50 to 100 mg IM once a week, men 100 to 200 mg IM once a week. [Canada only: Injection 50, 100, 200 mg/mL.] >L 2X ►- ©III $$ OXANDROLONE (Oxandrin) Weight gain: 2.5 mg PO bid to qid for 2 to 4 weeks. [Generic/Trade: Tabs 2.5, 10 mg.] >L 2X ►? ©III $$$$$ TESTOSTERONE (Androderm, AndroGel, Delatestryl, Depo-Testosterone, Striant, Testim, Testopel, Testro AQ, ♦Andriol) Injectable enanthate or cypionate: 50 to 400 mg IM q 2 to 4 weeks. Transdermal: Androderm: 5 mg patch to non-scrotal skin qhs. AndroGel 1%: Apply 5 g from gel pack or 4 pumps (5 g) from dispenser daily to shoulders/upper arms/abdomen. Testim: 1 tube (5 g) daily to shoulders/upper arms. Pellet: Testopel: 2 to 6 (150 to 450 mg testosterone) pellets SC q 3 to 6 months. Buccal: Striant: 30 mg q 12 h on upper gum above the incisor tooth; alternate sides for each application. [Trade only: Patch 2.5, 5 mg/24 h (Androderm). Gel 1% 2.5, 5 g packet, 75 g multidose pump (AndroGel). Gel 1%, 5 g tube (Testim). Pellet 75 mg (Testopel). Buccal: Blister packs 30 mg (Striant). Generic/Trade: Injection 100, 200 mg/mL (cypionate), 200 mg/mL (ethanate).] >L 2X ►? ©III $$$$$

Bisphosphonates

ALENDRONATE (Fosamax, Fosamax Plus D, ♦Fosavance) Postmenopausal osteoporosis prevention (5 mg PO daily or 35 mg PO weekly) and treatment (10 mg daily, 70 mg PO weekly, 70 mg/vit D3 2800 international units PO weekly, or 70 mg/vit D3 5600 international units PO weekly). Treatment of glucocorticoid-induced osteoporosis: 5 mg PO daily in men and women or 10 mg PO daily in postmenopausal women not taking estrogen. Treatment of osteoporosis in men: 10 mg PO daily, 70 mg PO weekly, or 70 mg/vit D3 2800 international units PO weekly, or 70 mg/vit D3 5600 international units PO weekly. Paget's disease in men and women: 40 mg PO daily for 6 months. [Generic/Trade (Fosamax): Tabs 5, 10, 35, 40, 70 mg. Trade only: Oral soln 70 mg/75 mL (single-dose bottle). Fosamax Plus D: 70 mg + either 2800 or 5600 units of vitamin D3.] >K 2C ►- $$ CLODRONATE (*Ostac, Bonefos) Canada only. IV single dose, 1500 mg slow infusion over at least 4 h. IV multiple dose, 300 mg slow infusion daily over 2 to 6 h up to 10 days. Oral, following IV therapy, maintenance 1600 to 2400 mg/day in single or divided doses. Max PO dose 3200 mg/day; duration of therapy is usually 6 months. [Generic/Trade: Caps 400 mg.] >K 2D ►- $$$$$

ETIDRONATE (Didronel) Paget's disease: 5 to 10 mg/kg PO daily for 6 months or 11 to 20 mg/kg daily for 3 months. [Generic/Trade: Tabs 200, 400 mg.] >K 2C ►? $$$$

IBANDRONATE (Boniva) Treatment/Prevention of postmenopausal osteoporosis. Oral: 2.5 mg PO daily or 150 mg PO once a month. IV: 3 mg IV q 3 months. [Trade only: Tabs 2.5, 150 mg.] >K 2C ►? $$$$

PAMIDRONATE (Aredia) Hypercalcemia of malignancy: 60 to 90 mg IV over

2 to 24 h. Wait at least 7 days before considering retreatment. UK 2D ►? $$$$$

RISEDRONATE (Actonel, Actonel Plus Calcium) Prevention & treatment of postmenopausal osteoporosis: 5 mg PO daily, 35 mg PO weekly, 75 mg PO on 2 consecutive days each month, or 150 mg once a month. Treatment of osteoporosis in men: 35 mg PO weekly. Prevention & treatment of glucocorticoid-induced osteoporosis: 5 mg PO daily. Paget's disease: 30 mg PO daily for 2 months. [Generic/Trade: Tabs 5, 30, 35 mg. Trade only: 75, 150 mg; 35/1250 mg (calcium).] >K 2C ►? $$$

ZOLEDRONIC ACID (Reclast, Zometa, +Aclasta) Treatment of osteoporosis:

5 mg (Reclast) once yearly IV infusion over 15 min or longer. Prevention and treatment of glucocorticoid-induced osteoporosis: 5 mg (Reclast) once a year IV infusion over 15 min or longer. Hypercalcemia (Zometa): 4 mg IV infusion over 15 min or longer. Wait at least 7 days before considering retreatment. Paget's disease (Reclast): 5 mg IV single dose. Multiple myeloma and metastatic bone lesions from solid tumors (Zometa): 4 mg IV infusion over 15 min or longer q 3 to 4 weeks. UK 2D ► ? $$$$$

Corticosteroids

NOTE See also dermatology, ophthalmology.

BETAMETHASONE (Celestone, Celestone Soluspan, *Betaject) Antiinflammatory/Immunosuppressive: 0.6 to 7.2 mg/day PO divided bid to qid; up to 9 mg/day IM. Fetal lung maturation, maternal antepartum: 12 mg IM q 24 h for 2 doses. [Trade only: Syrup 0.6 mg/5 mL.] >L 2C ►-$$$$$

CORTISONE (Cortone) 25 to 300 mg PO daily. [Generic only: Tabs 5, 10, 25 mg.] >L 2D ►-$

DEXAMETHASONE (Decadron, Dexpak, *Dexasone) Anti-inflammatory/ Immunosuppressive: 0.5 to 9 mg/day Po/IV/IM, divided bid to qid. Cerebral edema: 10 to 20 mg IV load, then 4 mg IM q 6 h (off-label IV use common) or

1 to 3 mg PO tid. Bronchopulmonary dysplasia in preterm infants: 0.5 mg/kg

PO/IV divided q 12 h for 3 days, then taper. Croup: 0.6 mg/kg PO or IM for one dose. Acute asthma: age older than 2 yo: 0.6 mg/kg to max 16 mg PO daily for 2 days. Fetal lung maturation, maternal antepartum: 6 mg IM q 12 h for

4 doses. Antiemetic, prophylaxis: 8 mg IV or 12 mg PO prior to chemotherapy;

8 mg PO daily for 2 to 4 days. Antiemetic, treatment: 10 to 20 mg PO/IV q 4 to 6 h. [Generic/Trade: Tabs 0.5, 0.75. Generic only: Tabs 0.25, 1.0, 1.5, 2, 4,

6 mg; elixir 0.5 mg/5 mL; Soln 0.5 mg/5 mL, 1 mg/1 mL (concentrate). Trade only: Dexpak 13 days (51 total 1.5 mg tabs for a 13 days taper) Dexpak 6 days (21 total 1.5 mg tabs for 6 days taper).] >L 2C ►- $

FLUDROCORTISONE (Florinef) Mineralocorticoid activity: 0.1 mg PO 3 times a week to 0.2 mg PO daily. [Generic only: Tabs 0.1 mg.] >L £C ►? $ HYDROCORTISONE (Cortef, Cortenema, Solu-Cortef) 100 to 500 mg IV/

IM q 2 to 6 h prn (sodium succinate). 20 to 240 mg/day PO divided tid to qid. Ulcerative colitis: 100 mg retention enema qhs (laying on side for 1 h or longer) for 21 days. [Generic/Trade: Tabs 5, 10, 20 mg, Enema 100 mg/60 mL.] >L 2C $

METHYLPREDNISOLONE (Solu-Medrol, Medrol, Depo-Medrol) Oral (Medrol): Dose varies, 4 to 48 mg PO daily. Medrol Dosepak tapers 24 to 0 mg PO over 7 days. IM/Joints (Depo-Medrol): Dose varies, 4 to 120 mg IM q 1 to 2 weeks. Parenteral (Solu-Medrol): Dose varies, 10 to 250 mg IV/IM. Peds: 0.5 to 1.7 mg/kg PO/iV/IM divided q 6 to 12 h. Acute spinal cord injury: 30 mg/kg IV over 15 min, followed in 45 min by a 5.4 mg/kg/h IV infusion for 23 to 47 h. [Trade only: Tabs 2, 16, 32 mg. Generic/Trade: Tabs 4, 8 mg. Medrol Dosepak (4 mg, 21 tabs).] >L 2C $

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