Comparative Investigation Of The Photoinstability Of Local Antimycotics

Figure 9 Photodegradation of topical antimycotics (in lOmg/lOOml methanolic solution, Suntest CPS, UVfilter): chlorphenesin , sulbentine •»■ , cloxiquine Jft- , tolnaf-tate , naftifine-HCl time (min)

Figure 9 Photodegradation of topical antimycotics (in lOmg/lOOml methanolic solution, Suntest CPS, UVfilter): chlorphenesin , sulbentine •»■ , cloxiquine Jft- , tolnaf-tate , naftifine-HCl

Figure 10 Degradation products of naftifine HCl in methanolic solution after 30 min irradiation: 1.43 min: injection peak; 6.78 min: photoproduct (2); 5.58 min: photoproduct (J); 7.33 min: naftifine.

To compare the photoinstability of various local antimycotics these have been irradiated in methanolic solution (Figure 9).

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