N

conh2

oh conh2

02 pH=9

Scheme 54

Chloramphenicol (188) is well known for its instability under irradiation (also under solar light). The initial process in water is homolytic cleavage of the C-C bond and further evolution of the two radicals to give glycolic aldehyde (189), dichloroacetamide (190) and 4-nitrobenzaldehyde (191) (Scheme 55).187

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