Nh

NHMe hv(254nm) Me0H/H20 orMeOH

NHMe hv(254nm) Me0H/H20 orMeOH

2.2.2 Benzodiazepines. Benzodiazepines are generally photolabile, but the path followed in the degradation depends on the structure of each derivative and on conditions. Thus, diazepam (69) undergoes cleavage of the heterocyclic ring, the main products being the benzophenone (70) by irradiation at 320 mn in MeOH-HhO, and the dihydroquinazoline (71) by irradiation at 254 nm in MeOH (Scheme 25). The latter compound then suffers slow isomerisation to (72) as well as dechlorination and oxidation to (73) and (74).82 The intravenous anaesthesic midazolam (75) undergoes ring restriction to a quinazoline (76) (main path with solar light) as well as oxidation of the 5-fluorophenyl moiety to give (77) and then (78) (main path with artificial light, Scheme 26).83'84

Scheme 26

Scheme 26

HetN02

hv deareated Het= Heterocycle

Hetv Hetx

Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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