the lifetime of this species increases by two orders of magnitude in water, where benzophenone is almost photostable.

The present chapter has the following aims:

a. to offer an overview of reported photochemical reactions of drugs (see Sec. 2).

b. to discuss practical problems related with drug photoreactivity, such as the dependence on the physical state of the drug or drug preparation and the quantitative assessment of drug photostability (see Sec. 3).

c. to make reference to the possible ways for protecting a drug against photoreactions (see Sec. 4).

The ICH Guidelines on Drug Photostability are enclosed as an Appendix.

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