Platelet physiology

Physiological agonists cannot penetrate the plasma membrane barrier and therefore, they must first couple to specific interactive domains on the platelet surface membrane in order to trigger the sequence of activation signals (21 -29, reviewed by Ryningen and Holmsen in this book). The physiological agonists that are known to activate platelets include adenosine diphosphate (ADP), epinephrine (adrenaline), thromboxane A2 (Txj ), thrombin, and platelet activation factor (PAF). In addition, cell...

Table 1 Antiplatelet Antithrombotic drugs

Acetyl salicylic acid (aspirin), Nonsteroidal antiinflammatory drugs (NSAID), Phenylbutazone, Indomethacin, Ibuprofen, Fenoprofen, Fluriboprofen, Neproxen, Sulfinpyrazone, antioxidants (Butylated Hydroxytoluene, BHT Butylated Hydroxyanisole, BHA Dipheylamine, DPA). Benzydamine, Imidazole congeners, 9, ll-azo-13 oxa-15 hydroxy prostanoic acid, 9, ll-azoprosta-5-13 dienoic acid (U-51605), 9, ll(epoxmethano) prostanoic acid, l(isopropyl-2-indloy (l)-3 pyridyl-3-ketone (L-8027)....

Acknowledgements

Anupama R. Tate and Dr. Mahadev Murthy for their help in the preparation of this manuscript. This work was supported by grants from NIH HL-18880, Laboratory Medicine & Pathology and Biomedical Engineering Institute. 1. Marcus AJ, Zucker MB. The physiology of blood platelets. New York Crane and Scrutton, 1965. 2. Kowalski E, Niewiarowski S. Biochemistry of blood platelets. New York Academic Press, 1966. 3. Caen J. Platelet aggregation. Paris Masson and...