Cumulative Excretion after A Single IV Dose

Either 14C-DX-8951 -labeled DE-310 or ,4C-carrier-labeled DE-310 was intravenously administered to normal mice.

"C-DX-8951 -libeled DE-310

l4C-carrier-labtied DE-310

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Cumulative excretion of radioactivity {% of Dose)

Figure 3. Cumulative excretion of radioactivity 42 days after a single iv dose of l4C-DX-8951-labeled DE-310 and ,4C-cairier-labeled DE-310 to mice.

The plasma levels of radioactivity decreased with almost the same of 2.6 days for both of 14C-labeled DE-310s. 14C-DX-8951-labeled DE-310 and 14C-carrier-labeled DE-310 were excreted primarily into the feces and the urine, respectively, and the elimination of radioactivity within 42 days was 97% for the former and 98% for the latter (Fig. 3), while the elimination of 95% of radioactivity was completed within 18 days for the former. These

"C-DX-8951 -libeled DE-310

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Cumulative excretion of radioactivity {% of Dose)

results indicate that the carrier moiety of DE-310 is gradually degraded to molecular sizes susceptible of glomerular filtration.

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