Info

force as well as inter-polymer cross-linking formation . Then, we expected that such a solubility problem could advantageously turn into a driving force of block copolymer micelles. Indeed, the ligand substitution reaction between CDDP and PEG-PAsp block copolymer in aqueous media led to the spontaneous formation of polymeric micelles (PEG-PAsp(CDDP) micelles) having a diameter of approximately 20 nm with a considerably narrow distribution (Fig. 4) 81, 82.

Figure 5. (A) Time change in the relative scattering light intensity (■) and CDDP release (A) for PEG-PAsp(CDDP) micelles in physiological saline at 37*C (Reprinted with permission from Ref. [82], Copyright 1999 American Chemical Society.). (B) Time profiles of free CDDP (A) and PEG-PAsp(CDDP) micelles (■) in the plasma in LLC-bearing mice (n = 4). Free CDDP or PEG' PAsp(CDDP) micelles were administered intravenously at a dose of 4.7 mg/kg on a CDDP basis 10 days after the tumor inoculation (tumor weight: 0.13 ± 0.04 g). (Reprinted with permission from Ref. [9|. Copyright 2001 Kluwer Academic.),

Figure 5. (A) Time change in the relative scattering light intensity (■) and CDDP release (A) for PEG-PAsp(CDDP) micelles in physiological saline at 37*C (Reprinted with permission from Ref. [82], Copyright 1999 American Chemical Society.). (B) Time profiles of free CDDP (A) and PEG-PAsp(CDDP) micelles (■) in the plasma in LLC-bearing mice (n = 4). Free CDDP or PEG' PAsp(CDDP) micelles were administered intravenously at a dose of 4.7 mg/kg on a CDDP basis 10 days after the tumor inoculation (tumor weight: 0.13 ± 0.04 g). (Reprinted with permission from Ref. [9|. Copyright 2001 Kluwer Academic.),

It was found that such micelle formation occurred above a critical ligand substitution ratio (CDDP/Asp > 0.5), and thus formed micelles had

0 0

Post a comment