lysosome, while the photodamage by DPs toward them was negligible . From these observations, the efficient phtodynamic effect of 32(+)DPZn may be due to photo-inactivation of specific target molecules (e.g., transporters, ion channels, cytoskeletons or lipids) in the plasma and subcellular membranes, although such exact molecular targets for the efficient PDT are an issue to be clarified in future. Another important aspect of DPs is their applicability to drug delivery systems. Namely, the surface charges of DPs might provide an opportunity to be encapsulated into PIC micelles. Indeed, both 32(+)DPZn and 32(-)DPZn formed PIC micelles through an electrostatic interaction with PEG-PAsp and PEG-poly(L-lysine) (PEG-PLys) block copolymers, respectively, and those micelles were confirmed to be stable in physiological saline (37 °C) (Fig. 6) 101. The research towards in vivo antitumor activity of DPs-incorporated PIC micelles is now ongoing in our laboratory.




PEG-PLys Nf-b+Br

Figure 6. Schematic structures of (A) third-generation ionic dendrimer porphyrins, (B) PEG-PAsp and (C) PEG-PLys block copolymers.

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