Ovarian Cancerbenefits Of Hpma Copolymer Conjugation

Doxorubicin (adriamycin), a well studied anticancer agent, has shown efficacy in the treatment of human ovarian epithelial carcinoma. [26] Doxorubicin acts by reversibly stabilizing covalent adducts between topoisomerase II and DNA and additionally generates free radicals. These activities result in DNA breaks, cellular membrane damage and cell death. [27, 28]

Doxorubicin possesses two specific dose-limiting toxicities: cardiotoxicity and bone marrow supression. [29, 30] It has been suggested that the dose-limiting cardiotoxicity of doxorubicin is mediated by oxygen radical formation which damages mitochondrial membranes and decreases superoxide dismutase activity, resulting in the further generation of reactive oxygen species and additional cellular damage. [31] HPMA copolymer delivery of doxorubicin reduces these risks, and demonstrates efficacy, reduced toxicity and immunogencity and great promise in human trials.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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