PEGPAsp Dox Micelles

PEG-PAsp(Dox) micelles are a first generation of polymeric micellar drug developed in our laboratory (Fig. 2) 8, 50. In this formulation, Dox was covalently linked to the side chain of the PAsp segment via an amide bond between the carboxylic group in PAsp and the primary amino group of the glycosidyl residue in Dox. Chemical conjugation of Dox into the PAsp segment with substitution ratio of approximately 50 % provided the PAsp segment with sufficient hydrophobicity to form a stable inner core of polymeric micelles 51.

Pol ¡»(ethyl toe glycol] Drug-conjugated p»[y(a,i3-iuperTIC acid) hydrophilic segment hydrophobic sigmerl

Pol ¡»(ethyl toe glycol] Drug-conjugated p»[y(a,i3-iuperTIC acid) hydrophilic segment hydrophobic sigmerl

CHa-(QCHsCH!>n-NH-(COCHNH)^CCCHiCHNHV-h
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