PH Dependence of Aqueous Solubility

It is well known that the solubility of a compound containing one or more ionizable functional groups will usually be a strong function of the pH of the dissolving aqueous medium, with the graphical representation of these qualities being known as the pH-solubility profile. Generally the solubility of a free acid is much less than the solubility of its ionized form, as has been illustrated in Figure 3

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