Solubility phenomenon is strongly related to the intermolecular forces between solute-solute, solvent-solvent, and solute-solvent. Based on the classic thermodynamics of solubility, many models have been developed to predict solubility when a direct measurement is impossible. On the other hand, solubility, along with its related properties, frequently provides a way to look into the structure of a drug substance and interaction between the drug substances at the molecular level. Solubility phenomenon is especially important in pharmaceutical industry. Relative solubility of various forms of a drug substance indicates their relative stability. The bioavailability of a drug substance is essentially determined by the dynamics and kinetics of solubility of the drug substance. A better understanding of the solubility and its related properties is critical in the development process of a drug candidate.
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