Effects on the Liver and Adrenal

Although vinclozolin and its metabolites do not bind the glucocorticoid receptor [109], treatment has been shown to alter the pituitary-adrenal axis in several mammalian species. Also noteworthy are the effects of vinclozolin and flu-tamide on liver function. Although short-term (7 day) and chronic treatments with these two chemicals increase liver size, the mechanism of action for the hepatic effects of these antiandrogens has not been elucidated, and the role of AR in this process, if any, is unknown.

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