One metabolite of DDT was found to alter adrenal function with sufficient potency to be used as a drug to reduce adrenal androgen production. o,p'-DDD (mitotane) is used to treat adrenal steroid hypersecretion associated with adrenal tumors. In addition to this usage, lower doses of mitotane restored menstruation in 13 of 15 women with spanomenorrhea associated with hypertrichosis. Pregnancies occurred in 5 of 15 women during the treatment period [34, 59]. In addition to direct effects on adrenal steroid producing cells, mitotane is also useful in controlling excessive androgen levels in the blood by increasing androgen metabolism.
Was this article helpful?