Known Effects of PCBs PCDDs and PCDFs in Humans

In addition to drugs and plant substances, several pesticides and toxic substances have been shown to alter human reproductive function (listed above). An accidental high dose in utero exposure to PCBs and PCDFs has been associated with reproductive alterations in boys, increased stillbirths, low birth weight, malformations, and IQ and behavioral deficits [58]. In addition to the effects associated with this inadvertent exposure, relatively subtle adverse effects were seen in infants and children exposed to relatively low levels of PCBs, PCDDs, and PCDFs [36]. The authors reported that the LOAELs for developmental neurobehavioral and reproductive endpoints, based on body burdens of toxic equivalents (TEQs) in animals, are within the range of current human body burdens.

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