Known Effects of Plant Antiandrogens in Humans and Rodents

Permixon is an antiandrogenic extract of the saw palmetto that is used in some European countries to treat androgen-dependent prostatic diseases [53]. Clinical studies indicate that it is effective in this regard. Mechanistically, it has been reported to act as an AR antagonist [54] and to inhibit the activity of 5a-reductase activity, which metabolizes testosterone to dihydrotestosterone (DHT) [55]. Rhodes et al. [56] reported that permixon failed to inhibit testosterone- or DHT-stimulated prostate growth in castrated rats, suggesting that it was not antiandrogenic, while, in contrast, Paubert-Braquet et al. [57] reported that the lipidosterolic extract of Serenoa repens (permixon) inhibited the effects of estradiol in combination with testosterone on prostatic growth in castrated male rats. The developmental effects of this plant extract have not been determined.

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