Over the past decade, experimental and theoretical approaches have contributed to stressing the importance of interpreting protein interaction networks in the context of domain-domain and domain-peptide interaction preference. Unraveling the mechanisms by which modular domains mediate protein interactions will allow gaining a more insightful understanding of cell functioning in both physiological and pathological conditions. Only when this first step has been achieved will it be possible to progress towards ambitious goals, such as predicting the cell response to any given stimulus and attenuating undesirable phenotypes by selectively inducing or blocking protein interactions (Dueber et al. 2004).

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