Elucidation of AKAP Functions

Physiological functions of AKAPs have been elucidated by gene targeting in mice and knockdown experiments with RNA in various cultured cell types. Moreover, the disruption of direct AKAP-mediated protein-protein interactions with peptides in in vitro and cellular assays and animal models has revealed the involvement of AKAPs in a variety of cellular processes. In this chapter we will mainly focus on studies utilising peptides for disruption of direct AKAP-mediated protein-protein interactions. These studies point to AKAP-mediated protein-protein interactions as targets for novel drugs. Initially, we briefly discuss AKAP functions elucidated by gene targeting and gene silencing.

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