Protein Coupled Receptor Signaling Components in Membrane Raft and Caveolae Microdomains

Contents

1 Cellular Compartments as Signaling Microdomains: A General Overview 167

2 Specialized Plasma Membrane Compartments:

Membrane/Lipid Rafts vs. Caveolae 169

3 Determinants of Membrane Raft/Caveolae Localization 170

4 Membrane Rafts/Caveolae in Signal Transduction 171

5 GPCR/G-Proteins 172

5.1 Specific Signal Transduction Pathways 174

6 Questions to Consider for Future Investigations 178

References 179

Abstract The efficiency of signal transduction in cells derives in part from subcellular, in particular plasma membrane, microdomains that organize signaling molecules and signaling complexes. Two related plasma membrane domains that compartmentalize G-protein coupled receptor (GPCR) signaling complexes are lipid (membrane) rafts, domains that are enriched in certain lipids, including cholesterol and sphingolipids, and caveolae, a subset of lipid rafts that are enriched in the protein caveolin. This review focuses on the properties of lipid rafts and caveolae, the mechanisms by which they localize signaling molecules and the identity of GPCR signaling components that are organized in these domains.

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