MAPK as Drug Targets

As described above, the MAPK cascade regulates numerous cellular functions, many of which have been implicated in disease. The ability of this pathway to regulate growth factor signalling, differentiation, proliferation and immune responses has made it an attractive target for pharmacological agents targeting cancer or inflammatory disorders. Furthermore, the diversity of the signalling networks should enable drugs to target highly specific cellular responses, thereby reducing side effects. Here we discuss the current therapies directed against the MAPK pathway, and the signalling components that provide potential future targets.

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