P38 Pathway

There are four members of the p38 kinase family, namely a, p, y and 5. Cytokines, hormones, G-protein-coupled receptors and cell stress, for example, heat or osmotic shock, activate these enzymes (Pearson et al. 2001). p38 kinases, which are targets of both MEK3 and MEK6 (Fig. 1), have numerous substrates, including MAPK interacting kinases (Mnk) 1 and Mnk 2, and eukaryotic initiation factor 4e (eIF4e). p38 regulates angiogenesis, cell proliferation, inflammation and cytokine production.

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