Regulatory Networks Key Players Qualify by Diverse Interactions with SMARs or Scaffolds

Our simplified view (Sect. 3.2) that constitutive S/MAR elements interact with constitutive proteins such as SAF-A or lamins does not exclude the modulation of these contacts by cell-type-specific factors. Besides, there are examples for proteins that gain or lose function by their integration into the matrix via an NMTS or by interaction with specific factors at the matrix. As an example, nuclear receptors have already been mentioned that gain activity by their association with SAF-A (Sect. 4.2.2). The proteins discussed below are involved in more diverse functions. They either interact with a plethora of other factors (PARP functions will be elaborated exemplarily since the scope of its actions is under extensive present investigation) or they are cell specific. A particularly well-studied example from the latter group is SATB1, the first member of a class of cell-type-specific fibre-forming components, which forms a functional link between the central topics of Sects. 4 and 5.

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