The IKK Complex The Gatekeeper of NFkB Pathways

The complete absence of inducible NF-kB in IKKa/IKKP-deficient cells emphasizes the master-regulatory function of IKKs for type-1 and type-2 NF-kB activation in response to almost all known physiological stimuli. In this section we will focus on the data about the structure of the IKKs and discuss the functional implications. The biological functions of individual IKK family members have been intensively reviewed (Hacker and Karin 2006), and this section will only briefly highlight major areas in the context of structural constraints.

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