Therapeutic Interference with Coiled Coil Interactions

Among the structurally and functionally diverse coiled-coil proteins discussed so far, SNARE proteins (Sect. 2.2) and viral fusion proteins (Sect. 3) are of particular therapeutic relevance because they both represent targets of approved and widely employed drugs, botulinum toxins and fusion inhibitors. However, the specificity and reversibility of their association and the crucial roles they play in many central cellular processes suggest that many other coiled coils might also be considered promising targets for pharmacological interference.

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