Tissue Specific Downstream Effectors

Tissue-specific expression of downstream effectors and transcription factors may contribute to MAPK specificity (Tan and Kim 1999). While some tissue-specific MAPK-activated transcription factors have been found, including ELK-1, SAP, NET and HSF1

(Treisman 1996), most appear to be ubiquitous. Nevertheless, there may be more tissue-specific MAPK effectors that have not been identified, and this mechanism may yet prove to be important in providing signalling specificity to the MAPK cascade.

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