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Psoriasis Revolution

Psoriasis Revolution is a natural program that has been well researched by the experienced medical nutritionist and a psoriasis sufferer Dan Crawford. It is designed to guide users on how they can completely cure psoriasis and eliminate red, silvery scales, patchy itchy skin, haemorrhage and also boost the immune system, essentially a life-time solution. Psoriasis is not only a long-term solution, but also provides instant remedy to psoriasis. For example, the program can lower the burning sensation and itchiness within 24 hours. Although results will vary from one person to another, many users have reported significant results within 1 to 2 months of its use. Dan is a popular medical nutritionists, wellness adviser, research worker and a person who has suffered psoriasis for 27 years. Dan spent more than 12 years, 47,000 hours doing clinical analysis and a lot of money doing trial and error methods to develop a program that can truly cure any type of psoriasis at any level of severity. More here...

Psoriasis Revolution Summary


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Author: Dan Crawford
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The Psoriasis Strategy

Psoriasis is commonly referred to as a skin condition that quickness up the life cycle of skin cells. It is a condition that causes cells to build up rapidly on the surface of the skin. The extra skin cells form white patches known as scales and red patches, which are itchy and sometimes painful. Psoriasis is not a skin problem per se, but an inflammation problem which is connected to the immune system. The inflammation of the skin is what leads to a flaky, itchy, red skin condition that people living with psoriasis are used to. People suffering from this condition experience discomfort and low self-esteem the entire time. They have problems communicating, getting into intimate relationships, and being in public because all the time, they meet new people who will notice their condition. The only time psoriasis sufferers get comfortable is when they are indoors or in forums where they are all victims of the same situation. This condition lasts longer in some patients as compared to others. Medications, ointment, among other treatments, have been offered for psoriasis patients. The medicines seem to work and relieve pain for a shorter period then the side effects become even worse. The solution is simple and is known to many people. More here...

The Psoriasis Strategy Summary

Contents: Ebook
Official Website: paralyzepsoriasis.com
Price: $49.00

CD11a as a Target for Psoriasis Treatment

As discussed earlier in regard to target antigen binding correlated to Ab PK, CD11a is a heavily pursued target for psoriasis treatment. Surrogate Abs are a potential solution to the limited safety testing possible with humanized mAbs with restricted species cross-reactivity. A chimeric mouse rat anti-mouse CD11a mAb (muM17) was studied in the context of evaluating both in vitro and in vivo as a potential surrogate for efalizumab, a humanized anti-CD11a Ab in development for psoriasis (100). CD11a is a subunit of lymphocyte function-associated antigen-1, an integrin involved in cell-cell interactions important to immune responses and inflammation (100). Clarke et al. related in vitro binding, lymphocyte response, and tissue cross-reactivity of the anti-CD11a Ab muM17 to its in vivo toxicology (100). Results from in vitro and in vivo pharmacology studies showed similar pharmacological and toxicological activities, thereby justifying the use of muM17 as a surrogate for efalizumab (100).

Other Routes Of Administration

When a compound is administered by topical application, the target is normally, but not always (e.g. a nicotine patch), local as with local anaesthetics. There is a fatty protective barrier on the skin that the substance has to traverse. The substance may therefore be applied in a solvent or as a cream that helps it to cross this barrier. A fat-solubilizing group such as ester may be chemically attached to the drug. This group may be removed subsequently by esterases within the body to reveal the active drug once it has crossed the barrier. The esterification of cortical steroids that are used in creams to alleviate skin conditions such as psoriasis, exemplifies this.

Stratum Corneum Effects

The stratum corneum is the most easily accessed part of the skin itself, and there are two actions targeted to this tissue, namely, emolliency, the softening of the horny tissue, which comes about through remoisturizing it, and keratolysis, the chemical digestion and removal of thickened or scaly horny tissue. Tissue needing such removal is found in calluses, corns, and psoriasis and as dandruff. Common agents as salicylic acid and, to a lesser extent, sulfur, cause lysis of the sulfhydral linkages holding the keratin of the horny structure together, leading to its disintegration and sloughing.

Sea Anemone Toxins Interacting with Kv1 Channels

All these toxin-channel interaction studies have assisted in the design of new types of toxins, such as ShK-Dap22 a mutant peptide where K22 has been replaced by a diaminopropionic acid. Binding and electrophysiological studies have shown that ShK-Dap22 is a highly potent and selective blocker of the Kv1.3 channel with a 100-fold decreased affinity for Kv1.1, Kv1.4 and Kv1.6 channels (Kalman et al. 1998). NMR studies have shown that the overall structures of ShK and ShK-Dap22 are quite similar, but there are differences in the side chains involved in Kv1.3 binding (Kalman et al. 1998 Norton et al. 2004). A high expression level of Kv1.3 is considered as a marker for activated effector memory T cells (TEM cells), which are involved in the pathogenesis of autoimmune diseases. Therefore, the selective suppression of autoreactive TEM cells with Kv1.3 blockers might constitute a novel approach for the treatment of multiple sclerosis (MS) and other autoimmune diseases such as type-1...

Sequence Optimization for Cellular Uptake

Figure 7.6 Fluorescence micrographs (magnification 200 x) demonstrating the uptake of a Texas Red-labelled Stat-1 decoy ODN (18-mer) ointment into human skin samples (red) derived from a patient with psoriasis ex vivo at the indicated time points. Nuclear localization was assessed by DAPI staining (blue). Figure 7.6 Fluorescence micrographs (magnification 200 x) demonstrating the uptake of a Texas Red-labelled Stat-1 decoy ODN (18-mer) ointment into human skin samples (red) derived from a patient with psoriasis ex vivo at the indicated time points. Nuclear localization was assessed by DAPI staining (blue).

Precautions And Contraindications

Chloroquine is not recommended for treating individuals with epilepsy or myasthenia gravis. The drug should be used cautiously if at all in the presence of hepatic disease or severe GI, neurological, or blood disorders. The dose must be adjusted in renal failure. In rare cases, chloroquine can cause hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Chloro-quine should not be used in patients with psoriasis or other exfoliative skin conditions because it causes severe reactions. It should not be used for malaria in patients with porphyria cutanea tarda but is used in smaller doses for treatment of the underlying disease (see Chapter 63). Chloroquine inhibits CYP2D6 and interacts with a variety of drugs. It should not be given with mefloquine because of increased risk of seizures. Most important, this antimalarial opposes the action of anti-convulsants and increases the risk of ventricular arrhythmias from coadministration with amiodarone or halofantrine....

Aminolevulinic Acid Photodynamic Therapy

In addition to skin cancers, ALA-PDT has also been used to treat skin conditions such as acne vulgaris, warts, condylomata, scleroderma, nevus sebaceous and psoriasis, as well as nondermatological applications such as carcinomas of the digestive system, respiratory system and urogenital system 22 .

Novel alternative immunotherapeutic approaches using chimeric proteins not intrinsic toxins

Recently, CTLA4Ig has entered human trials in normal volunteers and in patients with psoriasis vulgaris. CTLA4Ig was well tolerated by patients and showed dose-dependent ability to block antibody responses to two T-cell-dependent antigens, KLH and bacterio-phage f X174 (Lebwohl et al., 1997). Dose-dependent improvement in psoriasis was also produced, with 5 6 patients showing 50 improvement in clinical scores after 4 infusions with 25 mg kg of CTLA4Ig (Lebwohl et al., 1997). Objective histopathological measures of psoriasis disease activity - epidermal hyperplasia, T-lymphocyte infiltration into diseased tissue, and the expression of inflammation-associated proteins were also reduced in patients following administration of CTLA4Ig (Krueger et al., 1997). The conclusion from these experiments is that psoriatic disease persistence may be dependent on ongoing T-cell costimulation. Furthermore, these trials provide the proof of principle that blockade of counter-receptors expressed on...

Antitumor agents targeted at lysosomes

Kahalalide F is a depsipeptide derived from the sea slug Elysia rufescens. This compound alters the function of the lysosomal membranes, a mechanism that distinguishes it from all other known antitumor agents. Other mechanisms of action are inhibition of the TGF-a expression, blockade of intracellular signaling pathways downstream of EGF and ErbB2 receptor family, and induction of non-p53-mediated apoptosis. Kahalalide F is currently in Phase II clinical trials in hepatocellular carcinoma, non-small cell lung cancer (NSCLC), and melanoma, and is also being evaluated for the treatment of severe psoriasis. In these studies, kahalalide F has shown limited activity but an excellent tolerability profile that merits further clinical evaluation in combination with other anticancer compounds.

Structure and Function of Human Skin

Human skin is a highly efficient, self-repairing barrier which permits terrestrial life by regulating heat and water loss from the body while preventing the ingress of noxious chemicals or micro-organisms. It is the largest organ of the human body providing around 10 of the body mass of an average person and an area of approximately 1.8 m2. The tissue can be examined at various levels of complexity. Simplistically, skin can be regarded merely as a physical barrier with more sophistication introduced by considering the various skin layers, providing barriers in parallel. We can introduce barriers in series by considering drug transport through pores in the tissue. Degrees of complexity also exist when examining basic structures and functions of the membrane. In some extreme cases it may be that topical drug delivery is limited by metabolic activity within the membrane. Alternatively, immunological responses may prevent the clinical use of a formulation that has proven to be optimal...

Clinical Aspects of CD26 Role in Immune Disorders

It has been reported that the signaling capacity of soluble DPP4 mediates immune function 105,140 . Many clinicians reported the altered level of serum DPP4 enzyme activity in various immune-mediated diseases (Table 1), including bronchail asthma 141 , allogeneic kidney transplantation 20 , atopic dermatitis 142,143 , Graves' disease 144 , IBD 16,145 , MS 146 , psoriasis 143,147 , RA 15,103,148,149 , systemic sclerosis (SSc) 151 , SLE 17,103,150 , ANCA (antineutrophil cytoplasmic antibodies)-associated vasculitides 152,153 . Changes in serum DPP enzyme activity is originally attributed to DPP4, while the substrates used to assess enzyme

Chlorhexidine Gluconate

Uretane And Grignard Reactions

Mercury and its derivatives have been used in medicine for centuries. Elemental mercury incorporated into ointment bases was used topically for the treatment of localized infections and syphilis. Several inorganic salts of mercury, such as mercuric chloride (HgCl2) and mercurous chloride (calomel, Hg2Cl2) were at one time widely used as antiseptics. Ammoniated mercury Hg(NH2)Cl is still occasionally used for skin infections such as impetigo, psoriasis, and ringworm. Mercuric oxide is sometimes used to treat inflammation resulting from infection of the eye. Although the potential interaction of mercuric ion with the tissues is greatly reduced by the low water solubility of these agents, they can be irritating and can cause hypersensitivity reactions therefore, their use is not recommended.

In Vitro Binding Correlated To In Vivo Properties

Target Antigen Binding Correlated to Antibody Pharmacokinetics The exploration of cluster of differentiation (CD)11a as a target for psoriasis treatment illustrates how target antigen expression can affect Ab PK. Efalizumab (anti-CD11a, Raptiva ) has been approved for treatment of moderate to severe psoriasis, a chronic skin disease involving T cells, and its PK and PD have been reviewed by Joshi et al. (38). This Ab binds the subunit CD11a of the human integrin lymphocyte function-associated antigen-1, and interferes with the T-cell infiltration, activation, migration to the skin, and reactivation process, all hallmarks of the disease. Coffey et al. used an in vitro human T-cell model to study cellular uptake and clearance of the anti-CD11a Ab (39). Flow cytometric analysis was used to examine the cell surface and intracellular expression of CD11a following in vitro incubation of anti-CD11a with human T cells, demonstrating downmodulation of both surface and intracellular CD11a...

Diseased Compromised Skin and Solvent Selection

Erupted skin surface will allow increased water loss from the body. Psoriasis is a chronic recurring non-infectious scaling skin condition characterised by erythematous plaques covered with silvery scales. For topical therapy the loss of skin barrier integrity has been shown to be valuable for targeting drugs to the required site of action while minimising side effects (Anigbogu et al., 1996). Lichenoid eruptions are characterised by intensely itchy flat-topped papules while eczema is a further non-infectious eruptive condition, in which blistering occurs. Contact dermatitis can result from a direct irritant action of a substance on the skin (irritant contact dermatitis) or further exposure, following previous sensitisa-tion of the skin, from a contact allergen (allergic contact dermatitis). Irritant dermatitis is the more common of the two manifestations, and can be caused by many chemicals, solvents and detergents sodium lauryl sulphate was used to induce irritant dermatitis before...

About the Editors Authors and Associates

Related areas such as phytochemistry, biological activities of natural products, and quality control issues and methods relevant to botanical products. Dr. Soumayanath's research has focused on investigating traditional plant remedies used in the treatment of vitiligo, psoriasis, and diabetes, both in terms of defining their modes of action and as sources of potential new therapeutic agents for these diseases.

Staughton Laurocapram Emulsio

Eczema and psoriasis remedies. In Griffernhagen GB, Hawking LL, eds. Handbook of Non-Prescription Drugs. Washington, DC American Pharmaceutical Association, 1973 161-166. 23. Voorhees JJ, Duell EA, Stawiski M, et al. Molecular and clinical pharmacology of psoriasis. Clin Pharmacol Ther 1974 16(5 pt 2) 919-921.

Miscellaneous Immunosuppressant And Antiinflammatory Agents

Mycophenolate mofetil is used increasingly to treat inflammatory and autoimmune diseases in dermatology in doses ranging from 1 to 2 g day orally. Mycophenolate mofetil is particularly useful as a corticosteroid-sparing agent in the treatment of autoimmune blistering disorders, including pemphigus vulgaris, bullous pemphigoid, cicatricial pemphigoid, and pemphigus foliaceus. It also has been used effectively in the treatment of inflammatory diseases such as psoriasis, atopic dermatitis, and pyoderma gangrenosum.

Antisense Oligonucleotides

Paper Dna Printable Pattern

Of the ON is sufficient to activate RNase H.8 Interestingly, replacement of the phosphodiester bond by phosphorothioates throughout the gapmer allows further gain in nuclease stability without increasing the toxicity of the ON - a phenomenon that is not yet fully understood. Gapmer ONs that consist of MOE and phosphorothioate DNA monomers are currently in clinical development against a broad range of diseases, including diabetes, high cholesterol level, multiple sclerosis, psoriasis and cancer (Table 1.1). Psoriasis

Modeling Of Antibody In Vitroin Vivo Correlations

In the case of anti-CD11a in the treatment of psoriasis, mechanism-based modeling assisted the optimal clinical dose regimen selection (31). In vitro binding studies of anti-CD11a to CD11a on the surface of human T cells were conducted, and the binding affinity constant was measured. It was observed in the early clinical trials that intravenous doses of anti-CD11a higher than 0.3 mg kg saturated CD11a binding sites, and the receptor clearance was dependent on the plasma concentration of Ab (40). A two-compartmental TDDM model was proposed to model the clearance of anti-CD11a coupled with a feedback loop of CD11a to the clearance of anti-CD11a (153). From this model, the affinity of anti-CD11a to CD11a was estimated on the basis of in vivo data and was very similar to the in vitro estimates. This model was subsequently studied both in vitro and in vivo (39,40). Collectively, these studies and modeling exercises provided a sound basis for further optimal dose selection to guide future...

Science And Technology Advances In Biomarker Research

Of diseases with common phenotype presentations. Among the databases being established for enabling researchers public access to these association studies is dbGaP, the database of genotype and phenotype. The database, which was developed and is operated by the National Library of Medicine's National Center for Biotechnology Information, archives and distributes data from studies that have investigated the relationship between phenotype and genotype, such as GWASs. At present, dbGAP contains 36 population-based studies that include genotype and phenotype information. Worldwide, dozens if not hundreds of GWASs are under way for a plethora of health and disease conditions associated with genetic features. Many of these projects are collaborative, involve many countries, and are supported through public-private partnerships. An example is the Genomics Association Information Network (GAIN), which is making genotype-phenotype information publicly available for a variety of studies in...

Cytotoxic And Immunosuppressant Drugs

Cytotoxic and immunosuppressive drugs are used in dermatology for immunologically mediated diseases such as psoriasis, the autoimmune blistering diseases, and leukocytoclastic vasculitis. These agents are discussed in detail in Chapters 51 and 52. methotrexate The antimetabolite methotrexate suppresses immunocompetent cells in the skin, and it also decreases the expression of cutaneous lymphocyte-associated antigen (CLA)-positive T cells and endothelial cell E-selectin, which may account for its efficacy in psoriasis. It is useful in treating a number of other dermatological conditions, including pityriasis lichenoides et varioliformis, lymphomatoid papulosis, sarcoidosis, pemphigus vulgaris, pityriasis rubra pilaris, lupus erythematosus, dermatomyositis, and cutaneous T-cell lymphoma. Methotrexate (rheumatrex, others) is equally effective as orally administered cyclosporine for the treatment of moderate-to-severe chronic plaque psoriasis. Methotrexate is used often in combination...

Dermatological Pharmacology The Structure And Function Of Skin

Altered barrier function In many dermatological diseases, such as psoriasis, the stratum corneum is abnormal, and barrier function is compromised. In these settings, percutaneous absorption may be increased to the point that standard drug doses can result in systemic toxicity (e.g., hypothalamic-pituitary-adrenal axis suppression can result from systemic absorption of potent topical glucocorticoids).

Adverse effects

Weight gain is greater in patients who are overweight to begin with. Some patients show decreased thyroid levels and rarely goiter. About 5 develop hypothyroidism and 30 have elevated thyroid-stimulating hormone levels. Polyuria (passing an excessive quantity of urine) or polydipsia (excessive thirst) occurs in one out of five patients. Aggravation of psoriasis and alopecia can occur but hair usually re-grows with or without the lithium.


The behavior of the epidermis when distended is also of importance. It is the stratum corneum's role to fend against tearing (2). This tissue is actually stronger per unit mass than the dermal fabric and, as a rule, is sufficiently elastic to adjust to stretching. Its pliability, however, is conditional, and it fissures and cracks if stretched when excessively dry. Arid atmospheres alone can produce this condition (windburn). Detergents and solvents, which extract essential, water-sequestering lipids from the stratum corneum, and diseases such as psoriasis associated with a malformed horny structure render the stratum corneum brittle and prone to Assuring.

Other Diseases

In a variety of other diseases inflammation is a pathological hallmark.These diseases include asthma, psoriasis and organ transplant rejection episodes 13 . Even Alzheimer's disease exhibits an inflammatory component 33 . Although the aetiology of these diseases differs to a large extent, they are all characterized by ongoing leucocyte recruitment and cytokine production. Therefore, they represent potential target diseases for treatment with endothelium-directed drug targeting constructs. Due to space limitations, these diseases will not however be discussed further.

Clinical Development

Clinical indications in which decoy ODNs have been studied thus far comprise asthma, psoriasis and atopic dermatitis. Here, decoy ODNs directed against the transcription factors Stat-1 (asthma, psoriasis) and NF-kB (atopic dermatitis) are in extended Phase IIa trials. While the results of the Phase I trials suggest that topical application of the Stat-1 decoy ODN (inhalation, ointment), as well as that of the NF-kB decoy ODN ointment (see www.anges-mg.com), is safe and well-tolerated, the Phase IIa data for the Stat-1 decoy ODN, though on the basis of a rather limited statistical power, also demonstrate efficacy in both indications (see www.avontec.de). The same was true for topical administration of Avrina's, formerly Corgentech's, NF-kB decoy ODN drug candidate, in a Phase I II trial in patients with atopic dermatitis (see www.anesiva.com). Another decoy ODN developed by the same company and directed against the transcription factor E2F has even completed two large-scale Phase III...


EGFR less than 10mL minute 1.73m2 Pregnancy see notes above Breast-feeding see notes above Side-effects see notes above also ileus, dry mouth tachycardia, palpitation, arrhythmias, angina, transient ischaemic attacks, cerebral haemorrhage, myo-cardial infarction, syncope dyspnoea, bronchitis asthenia, nervousness, sleep disturbances hot flushes alopecia, sweating, skin reactions including Stevens-Johnson syndrome, toxic epidermal necro-lysis, and psoriasis-like efflorescence Dose

Therapeutic Uses

Vitamin A is used in the treatment of known or suspected vitamin A deficiency. Vitamin A deficiency in developed countries such as the United States is not likely of dietary origin but is more likely caused by malabsorption as is seen in sprue, hepatic cirrhosis, biliary, or pancreatic diseases. Interestingly, vitamin A levels decrease during infection with the measles virus (rubeola) resulting in increased morbidity and mortality, especially in children with preexisting vitamin A deficiency. Vitamin A supplementation has been shown to decrease mortality by 50 and prevent blindness in children developing measles if given at the time of diagnosis. Of course, vaccination is of prime importance however, in underdeveloped countries where the rate of vaccination is low, vitamin A supplementation is a beneficial alternative.41 Retinoate analogs have been developed for use in the treatment of dermatological conditions such as psoriasis and acne. Some therapies for cancer by retinoate analogs...

Vitamins Vitamin A

Retinoids have been used as pharmacologic agents to treat disorders of the skin. Psoriasis, acne, and rosacea have been treated with natural or synthetic retinoids. Moreover, retinoids are effective in treating symptoms associated with congenital keratinization disorder syndromes. Therapeutic effects stem from its antineoplastic activity (Brzezinska-Wcislo et al. 2004). Patients suffering from these illnesses may be supplementing with vitamin A and their dosages should be explored.

Il7 Gene Therapy

IL-2 can be given by subcutaneous or intravenous injection or infusion. Its toxicity has limited its widespread use in patients. The vast majority of patients are affected by the grade I II toxicities commonly associated with other cytokines, including fever, nausea and vomiting, diarrhoea, fatigue, myalgia and arthralgia. Erythema at the site of injection is also common. The most severe toxicities occur at higher doses and are associated with a vascular leak syndrome, which is manifested by hypotension, tachycardia and oliguria, and can result in multiorgan damage (Table 10.4). This syndrome is thought to be mediated by nitric oxide produced in response to local secondary release of cytokines such as TNF, IL-1 and IFN-7. A number of TNF inhibitors have been evaluated in order to reduce this but with little benefit (Margolin et al., 1997). Autoimmune phenomena can occur following treatment with IL-2 (Gaspari, 1994). These include hypothyroidism, pemphigus, psoriasis and vitiligo....

Calcitriol Rocaltrol

In addition to controlling calcium and phosphate metabolism, calcitriol also has an immunomodulating effect that may be useful for the treatment of autoimmune diseases. It has already been approved for the topical treatment of immune-mediated skin disease, such as psoriasis. Calcitriol also has been found to induce apoptosis (biochemically-programmed cell death) in some cancer cells.

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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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