Selective NRI Safety and Tolerability

The side-effect profiles of reboxetine, atomoxetine, and viloxazine can be attributed to the unwanted effects of norepinephrine, as activity at other receptors is limited. The concept of selectivity can thus be a bit deceiving. While an agent such as reboxetine is selective for the neurotransmitter norepinephrine, its activity is nonse-lective in terms of distribution, contributing to effects not only in the brain but in the body as well (Table 3). In the limbic system, the stimulation of...

Advantages and Limitations of Microdialysis

Since its first applications, microdialysis has become increasingly popular to study brain function. The use of alternative in vivo procedures such as push-pull perfusion or voltammetry has remained constant or even declined during last years. A comparison between microdialysis and voltammetry reveals that microdialysis is applicable to most types of small molecules whereas the use of voltammetry is limited to easily oxidizable compounds such as catecholamines and serotonin. Moreover,...